6,7-Dihydroxybergamottin (DHB)

6,7-Dihydroxybergamottin (DHB) Reviews

6,7-Dihydroxybergamottin (DHB), also known as 6,7-DHB, is a natural furancoumarin found in the skin and flesh of grapefruit, and limes. It can effectively inhibit the activity of the cytochrome P450 3A sub-family of enzymes, especially CYP3A4. 6, 7-DHB is also responsible for blocking the activity of testosterone 6 beta-hydrolase. Pharmaceutical activity studies have shown that 6, 7-DHB can inactivate many enzymes in the cytochrome P450 enzyme series, which are related to the metabolism of many drugs. 6, 7-DHB can affect gastrointestinal absorption of drugs by affecting enzyme activity and increase the bioavailability of oral drugs. In addition, 6, 7-DHB can also inhibit the proliferation, invasion and migration of cancer cells, and has various biological activities such as anti-cancer, antibacterial and anti-mutagenesis.

How 6,7-Dihydroxybergamottin (DHB) Works

6, 7-DHB can significantly block the expression of testosterone 6-β hydrolase in human liver microsomes and CYP3A4 in E. coli membranes in a time and dose dependent manner. In addition, 6, 7-DHB has been shown to be a potent NADPH and time-dependent CYP3A4 inhibitor.

Health Benefits of 6,7-Dihydroxybergamottin (DHB)

The most notable role of 6, 7-DHB is as a CYP3A4 inhibitor, which is as follows:
Cytochrome P450 proteins (CYP) are the major enzymes responsible for drug metabolism in human body. They are a class of monooxygenases mainly present in liver and intestine, mostly located in the endoplasmic reticulum, and catalyze the metabolism of a variety of endogenous and exogenous substances (including most clinical drugs). There are several subfamilies of CYP, including CYP3A4, CYP3A5, CYP2D6, CYP2C9, CYP2C19, etc. CYP3A refers to the cytochrome P4503A4 enzyme and is the largest (about 30%) member of the cytochrome P450 family. It is mainly distributed in the liver and small intestine, and its main role is to participate in drug metabolism in the body, which can either inactivate drugs or activate drugs.
When the CYP3A4 enzyme partially destroys the drug, it accelerates the breakdown of the drug component in the intestine, resulting in a decrease in the bioavailability of the drug. As a CYP3A4 inhibitor, 6, 7-DHB does not react directly with drugs, but acts by regulating CYP3A4 in the gut. In other words, by selectively inhibiting the activity of CYP3A4 enzyme, the decomposition of drug components in the intestine is reduced, resulting in the drug entering the blood with the usual amount several times or even ten times, thus improving the absorption level of the drug by the human body, prolongating the use cycle of the drug, and greatly improving the efficacy of the drug. But because 6, 7-DHB inhibits CYP3A4 activity in the gut, only 6, 7-DHB works when administered orally, not intravenously.

6,7-Dihydroxybergamottin (DHB) Side Effects

Taking the appropriate dose of 6, 7-DHB has some benefit for patients. However, side effects such as heart palpitations, excessive sweating and increased heart rate may occur in overdose. In addition, children, pregnant and breastfeeding women should not use this compound. It should not be taken with urinary drugs, AIDS drugs, intestinal drugs, impotence drugs and psychotropic drugs.

Where to Buy High Quality 6,7-Dihydroxybergamottin (DHB)

Henan Steeda Industrial Co.,Ltd is a Reputed Manufacturer and Supplier Supplying High Quality Pharmaceutical, Nutraceutical and Cosmeceutical Ingredients. 6,7-Dihydroxybergamottin (DHB) is one of our most competitive ingredients with stocks available all year round. By providing high quality, we establish long-term relationships with our customers.

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