Benfotiamine

Benfotiamine Reviews

Thiamine, also known as vitamin B1, is an essential nutrient for normal cell growth, while benfotiamine is a synthetic thiamine. That is to say, benfotiamine is a fat-soluble vitamin B1 derivative, in addition to the physical and chemical properties and water-soluble vitamin B1 is different, the structural difference is that there is an open thiazole ring, in the body through the closed-loop action to form physiologically active vitamin B1. Compared to the water-soluble natural vitamin B1, fat-soluble benfotiamine has a higher bioavailability and can be better absorbed by the body. Benfotiamine appears as a white crystalline powder. Studies have proven that thiamine deficiency may cause diabetes and Alzheimer’s disease, but benfotiamine can combat the damaging effects of high blood sugar and metabolic diseases while helping to slow neurodegeneration. After taking benfotiamine drugs, absorption is fast and safe, and after entering the human circulation, rapid metabolism into thiamine, without increasing the concentration of drugs in the body, and then the generation of hippuric acid through the urine excreted.

How Benfotiamine Works

Benfotiamine acts both through the regulation of advanced glycation end products (AGEs) and through an age-independent pathway. First, we learned that advanced glycosylation end products are the products of excessive sugar and protein binding, and non-enzymatic glycosylation (Maillard reaction) occurs when exposed to sugar (such as aldose), which can cause tissue damage. AGEs can produce reactive oxygen species, attach to specific receptors, and form cross-linked structures. AGEs are present in the diabetic vascular system and are involved in the progression of atherosclerosis. Benfotiamine can inhibit the synthesis of AGEs, thereby reducing metabolic stress. Thus, benfotiamine is helpful in the treatment of vascular complications associated with diabetes. Secondly, benfotiamine also regulates age-independent pathways such as nuclear transcription factor κB, vascular endothelial growth factor receptor 2, and glycogen synthase kinase-3β (GSK-3β). It can also regulate mechanisms related to cell survival, repair, and apoptosis.

Health Benefits of Benfotiamine

Benfotiamine is mainly used for the prevention and treatment of beriberi, polyneuritis, peripheral neuritis, central nerve injury, myocarditis, and also for the auxiliary treatment of renal or liver insufficiency, hyperthyroidism, and diabetes. Here we will browes some of its important Health Benefits as below:
May help treat diabetes
Benfotiamine can increase the level of vitamin B1 in the body and has a good therapeutic effect on diabetes. In the process of glucose glucose metabolism, vitamin B1 (thiamine) plays the role of a coenzyme, by working with a variety of enzymes to promote glucose metabolism and energy production, reduce glucose deposition in the body, so as to effectively reduce blood sugar levels. In addition, benfotiamine can improve the health of diabetic patients by enhancing nervous system function and reducing neuropathy symptoms. On a microscopic level, vitamin B1 is closely related to the “little engines” in mitochondria that are involved in the body’s metabolism of glucose. As more glucose passes through these “little engines,” the higher the body’s blood sugar, the more vitamin B1 is consumed, causing tingling in the arms and legs, muscle fatigue, and blurry vision in addition to diabetes.
May help optimize thiamine deficiency
Thiamine (vitamin B1) deficiency can cause Wernicke-Korsakoff SyndromeW-KS and beriberi, the main symptoms of which include dyspnea, nystagmus (uncontrolled eye movement), heart rate failure, seizures, muscle weakness, visual impairment, mental deterioration, memory impairment, etc. If thiamine is severely deficient, complications including coma, heart failure, long-term nerve damage, or psychosis may occur. Symptoms such as difficulty breathing, inability to speak and paralysis can be life-threatening and require urgent medical attention. Because benfotiamine is a fat-soluble form of thiamine and has a higher bioavailability, benfotiamine may help reduce symptoms associated with vitamin B1 deficiency.
May help alleviate Alzheimer’s disease
The study found that the human brain, which accounts for only 2% of body weight, consumes around 20% of the body’s total glucose. Alzheimer’s disease may be associated with a decreased utilization of glucose in patients, and there is evidence that people with Alzheimer’s disease may reduce their utilization of glucose up to 30 years before the onset of dementia symptoms. The study also found that thiamine plays an important role in glucose metabolism. Moreover, the levels and activity of thiamine associated with thiamine dependent enzymes were reduced in the tissues and brains of Alzheimer’s patients. That is, thiamine supplementation can improve the absorption of glucose by the brain in Alzheimer’s patients, thereby optimizing cognitive function in Alzheimer’s patients. Benfotiamine can increase the level of thiamine, and fenthiamine has a higher utilization rate than thiamine, supplementing fenthiamine will be a good alternative choice.

Benfotiamine Side Effects

The safety of benfotiamine is high, and there is no need to worry about it under routine use. However, it should be noted that the side effects of benfotiamine are mainly in the very low probability of adverse reactions or allergies after medication, the adverse reactions are mainly headache, fatigue, irritability, appetite loss, edema, arrhythmia, etc., allergy manifestations are dizziness, fever, rash, rapid breathing, etc. In addition, benfotiamine should not be used with antacids such as sodium bicarbonate solution, basic drugs such as phenobarbital tablets, aminophylline tablets and other drugs.

Where to Buy High Quality Benfotiamine

Henan Steeda Industrial Co.,Ltd is a Reputed Manufacturer and Supplier Supplying High Quality Pharmaceutical, Nutraceutical and Cosmeceutical Ingredients. Benfotiamine is one of our most competitive ingredients with stocks available all year round. By providing high quality, we establish long-term relationships with our customers.

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