Beta-Nicotinamide Mononucleotide (Beta-NMN)

Beta-Nicotinamide Mononucleotide (Beta-NMN) Reviews

NMN exists in two irregular forms, α and β, and β isomer is the active form of NMN. Nicotinamide mononucleotide (NMN) is a naturally occurring bioactive nucleotide. It is the main precursor of nicotinamide adenine dinucleotide (NAD+), which is a very important basic enzyme in our body and plays an important role in physiological functions such as metabolism, DNA repair, cell growth and reproduction. The molecule is composed of nicotinamide, ribose and phosphate groups and is a synthetic substrate for Coenzyme I. The appearance of β-nicotinamide mononucleotide is white to slightly yellow, is a crystalline powder, no obvious odor, mainly found in broccoli, avocados, cabbage, cucumbers and edamame and other foods. NMN is mainly used in anti-aging research and has an important role in improving metabolism, cardiovascular and neurological function.

How Beta-Nicotinamide Mononucleotide (Beta-NMN) Works

After entering the body, NMN (β-nicotinamide mononucleotide) can be directly converted into NAD+ (nicotinamide adenine dinucleotide) molecules. NAD+ plays a key regulatory role in more than 400 metabolic reactions, including three key proteins closely related to cellular aging mechanisms: PARP1 (DNA repair enzyme), Sirts (acetylase, also known as “longevity protein”), and CD38 (specific immunosuppressive protein).

Health Benefits of Beta-Nicotinamide Mononucleotide (Beta-NMN)

Beta-Nicotinamide Mononucleotide (Beta-NMN) has been associated with an array of potential health benefits, such as Anti-aging, Improving Athletic Performance, Repairing DNA, Improving Mitochondrial Function and so on, here we will browes some of its important Health Benefits as below:
Anti-aging
Research has shown that NAD+levels in various tissues of the human body gradually decrease with age, but maintaining cellular energy levels requires sufficient NAD+supply. The loss of NAD+ not only speeds up the damage of intracellular DNA, but also leads to human aging, dyslipidemia, hyperglycemia and other chronic metabolic problems. If it is possible to maintain NAD+ levels in older people, it may help slow down various aspects of the aging process. At present, we can improve NAD+levels by supplementing NAD+precursors, namely NMN. The increase of NAD+can enhance cellular energy metabolism, improve cardiovascular function, and enhance cognitive abilities, all of which are health issues that the human body will face with aging. Firstly, a decrease in energy metabolism in the middle-aged and elderly population is a common phenomenon during the aging process. Research on mice has found that supplementing with NMN can increase the loss of NAD+levels during aging, which can reduce age-related weight gain and improve the exercise ability of elderly mice. This indicates that an increase in NAD+levels can activate intracellular energy metabolism pathways. Moreover, NAD+is a coenzyme of various enzymes that can participate in intracellular oxidative phosphorylation processes and promote ATP production. In short, by increasing NAD+levels, NMN can enhance the energy production ability of cells, thereby improving the metabolic status of middle-aged and elderly people. Secondly, increasing NAD+can also improve the cardiovascular function of mice. In mouse experiments, increasing NAD+level has been shown to prevent heart damage caused by decreased blood flow. This study suggests that increasing NAD+levels during aging can protect cardiovascular function. In addition, cognitive decline is also one of the main manifestations of aging. The decrease in NAD+levels in brain cells is believed to impair mitochondrial function, which is also a partial reason for the decline in cognitive function with age. Research has shown that, NMN can inhibit the formation of beta amyloid plaques, which are common in neurodegenerative diseases such as Alzheimer’s disease. Moreover, in the case of reduced cerebral blood flow, increasing NAD+can maintain neuronal survival.
Improving Athletic Performance
Supplementing NMN can improve physical performance by enhancing muscle strength and endurance. Through continuous use of NMN for 12 weeks in elderly men aged 65 and above, it was found that compared to the placebo group, the NMN group showed significant improvement in lower limb muscle strength, as well as improvements in gait speed and grip strength. This indicates that NMN can reduce age-related muscle loss (known as sarcopenia), increase muscle strength, and improve exercise performance.
Repairing DNA
As we get older, the DNA strands in the body become more and more prone to breakage, and their ability to repair double helix structures also decreases. Scientists have found that supplementing NAD+precursors such as NMN can increase the activity of NAD+dependent PARP1 enzymes (PARP1 enzymes can repair double stranded DNA). Therefore, supplementing NMN can reverse DNA damage, avoid cancer and gene mutations. Moreover, NAD+synthesized by NMN can activate long-lived proteins (Sirtuins) to maintain DNA integrity. As is well known, every time a cell divides, the DNA (telomere) at the end of the chromosome becomes shorter. Longevity proteins can slow down the rate of telomere shortening with the assistance of NAD+, thereby increasing telomere stability.
Improving Mitochondrial Function
Mitochondria are organelles that exist in most eukaryotic cells and are enclosed by two layers of membranes. They are the structures that produce energy in cells and are responsible for converting energy sources from food into energy used by cells. Without mitochondria, cells cannot survive. NAD+is a key substance in mitochondrial productivity processes, NAD+deficiency can lead to mitochondrial abnormalities and may even affect the occurrence of neurological diseases such as Alzheimer’s disease (senile dementia). Professor Xiong Bo from Nanjing Agricultural University found that supplementing with NMN can improve the mitochondrial function of oocytes, promote mitosis, and reduce the reproductive harm of toxic chemicals. Moreover, studies on mice have shown that supplementing with NMN can effectively improve mitochondrial dysfunction.

Beta-Nicotinamide Mononucleotide (Beta-NMN) Side Effects

So far, there is no evidence that NMN can cause side effects in humans. However, long-term consumption of β-nicotinamide mononucleotides may have a certain impact on sleep, and may also lead to adverse reactions such as malnutrition, allergies, and increased levels of sex hormones.

Where to Buy High Quality Beta-Nicotinamide Mononucleotide (Beta-NMN)

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