Citrus Neohesperidin Dihydrochalcone

What is Citrus Neohesperidin Dihydrochalcone

Citrus Neohesperidin Dihydrochalcone (NHDC) belongs to the flavonoid derivatives (vitamin P), mainly obtained by hydrogenation of raw materials extracted from natural citrus plants. These extracted raw materials include naringin, hesperidin, and neohesperidin, mainly derived from the peels of natural plants such as Citrus in the Rutaceae family, such as tangerine peel, citrus green peel and citrus fruit. NHDC has strong antioxidant properties and important physiological activities such as reducing blood sugar and blood lipids, inhibiting fatty liver, and regulating immunity. As a green food additive, it can be used as essence, flavor enhancer, bitter inhibitor, sweetener and functional additive, and is widely used in food, medicine, cosmetics, feed and other industries.

Health Benefits of Citrus Neohesperidin Dihydrochalcone

Neohesperidin Dihydrochalcone has been associated with an array of potential health benefits, such as Antioxidant, Reducing Cholesterol, Reducing Blood Sugar, Treating Stomach Diseases and so on, here we will browes some of its important Health Benefits as below:
Antioxidant Properties
NHDC has stronger antioxidant activity than hesperidin. A study has shown that NHDC has a significant effect on clearing stable free radicals and reactive oxygen species, and is the most effective inhibitor of hydrogen peroxide and hypochlorite. The antioxidant activity of NHDC is also reflected in its ability to partially inhibit pigment deposition and browning caused by polyphenol oxidase, and significantly inhibit the upregulation of matrix metalloproteinase 1 (MMP-1) caused by infrared radiation, thereby protecting human skin from premature aging caused by exposure to infrared radiation. Therefore, it is an anti browning and brightening agent.
Reducing Cholesterol
The results of animal model experiments showed that NHDC can inhibit the activity of reductases HMG-COA and ACAT, significantly reduce the levels of plasma cholesterol and neutral lipids in animals, and prevent arteriosclerosis and circulatory system diseases. Meanwhile, NHDC can increase the high-density lipoprotein (HDI) content in animal plasma, thereby promoting cholesterol metabolism.
Reducing Blood Sugar
In recent years, studies have found that NHDC can lower blood glucose levels in animals. This is because NHDC can inhibit α – amylase in mammals to varying degrees, thereby reducing the absorption of sugar by the body, thus reducing blood sugar, which is very important in medicine, especially for patients with diabetes.
Treating Stomach Diseases
As a commonly used stomach acid lowering drug ranitidine, NHDC is expected to become a new ingredient in digestive agents because it can inhibit the activity of histamine and significantly reduce the secretion of stomach acid and pepsin. NHDC has the function of inhibiting gastric acid secretion, so it can be used as an antacid in combination with aluminum hydroxide gel or other antacids, so that the anti gastric acid effect of the latter can be improved, and it has great potential to become the raw material of new gastric drugs.
Protecting the Liver
NHDC can reduce the levels of ALT, AST, and hydroxyproline in the serum of mice with CCI induced liver fibrosis, and can also slow down cell degeneration, necrosis, and liver fibrosis process to varying degrees. In addition, the decrease of ALT and AST in serum can improve lipid metabolism and liver function, inhibit the formation of fatty liver and major arterial endothelial plaques.
Regulating Immunity
NHDC is added to feed as a sweetener not only because of its pleasant taste and ability to induce animal appetite, but also because of its probiotic properties. After adding NHDC to pig feed, the concentration of lactic acid in the intestinal lumen increased significantly, leading to a significant increase in lactic acid bacteria at the entrance of the cecum in piglets. It can affect the gut microbiota, regulate the body’s immune system, and reduce intestinal diseases.

Application of Citrus Neohesperidin Dihydrochalcone

NHDC can be used as essence, flavor enhancer, bitterness inhibitor, sweetener and functional additive, and is widely used in food, medicine, cosmetics, feed and other industries.
Food Additives
In the food industry, NHDC is mainly used as a sweetener, essence and flavor modifier. NHDC is a sweetener with low calorie that does not undergo heat conversion in the body and has physiological activities such as lowering blood sugar, cholesterol, and antioxidant activity. The sweetness of NHDC is 1500-1800 times that of sucrose, and it can be used in combination with sucralose, polyol sweeteners, saccharin, etc. It is widely used in beverages, alcoholic beverages, desserts, candies, etc. The aroma of NHDC is similar to that of maltol and ethyl maltol, which can improve the original flavor of food. Some foods have good nutritional value, but they also have unique odors. NHDC can be added as a flavor modifier to food to mask its original taste. For example, NHDC is added to walnut soybean milk to reduce walnut flavor. NHDC is added to tomato sauce to mask its vinegar and spicy flavor.
Pharmaceutical Raw Materials
NHDC can be used as a bitterness masking agent in drugs to mask the bitterness of the drug. For example, the European version of Viagra and pediatric ibuprofen suspension use hesperidin to mask the bitterness of the drugs. The most important thing is that NHDC has pharmacological effects such as antioxidant, cholesterol lowering, blood sugar lowering, treatment of stomach diseases, and protection of the liver, and can be used as a raw material for drugs to treat various diseases. For example, it can be used as the raw material for treating diabetes, hypertension and other diseases and new gastric drugs.
Cosmetics Raw Materials
NHDC, as a flavonoid compound, has whitening effects, manifested by promoting skin metabolism, clearing free radicals, and inhibiting melanin production. Research has found that NHDC has a strong inhibitory ability on tyrosinase, which is twice and 60 times that of vitamin C and β – arbutin, respectively. It is a novel whitening agent with great potential for application. In addition, the oral anti-inflammatory effect of NHDC can be used in oral cleaning and care products such as toothpaste and mouthwash.
Feed Additive
NHDC can be added to animal feed, which can effectively enhance the flavor and palatability of the feed, and increase the appetite of animals. This is because the combination of NHDC in sweeteners, such as neotame and sodium saccharin, can mask and improve the bitterness and metallic taste of certain components in animal feed (such as certain protein ingredients, vitamins, metal ions, and some pharmaceutical ingredients), greatly enhancing sweetness. In addition, NHDC can also improve the gut microbiota of animals, and its comprehensive effect promotes their growth.

Citrus Neohesperidin Dihydrochalcone Side Effects

The side effects of NHDC are currently not very clear and require more experiments to confirm.

Where to Buy High Quality Citrus Neohesperidin Dihydrochalcone

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