Diosgenin
Product Name | Diosgenin |
CAS Number | 56786-63-1 |
Molecular Formula | C27H42O3 |
Country of Origin | China |
Main Benefits | Used for Pharmaceutical and Nutraceutical |
OEM MOQ: 500 Units
Place of Origin: China
Bulk Package: 25kg/drum
Port: Shanghai, China
Payment terms: T/T, Letter of Credit, Western Union
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Diosgenin Reviews
Diosgenin, commonly known as saponin, is a phytosteroid sapogenin. It is mainly derived from legumes and dioscorea plants, such as yam, ginger, xanthium, pangolin, etc., but the most important source is fenugreek seeds. Diosgenin is a kind of natural phytoestrogens, which is an important basic raw material for the production of steroid hormones. According to traditional Chinese medicine, dioscorea zingiberensis has the functions of expelling phlegm, eliminating food and removing water, relaxing muscles and promoting blood circulation, and stopping malaria. Modern pharmacological studies have shown that it has strong anti-oxidation, anti-infection, anti-allergy, antiviral, anti-diabetes and anti-shock pharmacological effects, can be used to treat rheumatism, cardiovascular disease, lympholeukemia, cellular encephalitis, skin diseases, tumors and so on.
How Diosgenin Works
Although diosgenin has good physiological activity, its bioavailability is very low clinically due to its high hydrophobicity and low solubility in digestive fluid after oral administration, so it is almost difficult to absorb into the blood, which makes diosgenin can not play its pharmacological role, and to a large extent limits the clinical application of diosgenin preparations. On the contrary, the type of adulteration of diosgenin synthesis can produce synergistic effects and enhance the pharmacological activity of its components. Therefore, it is necessary to synthesize diosgenin derivatives with different structures through chemical modification and structural transformation in order to improve the solubility and dissolution of diosgenin and enhance its pharmacological action.
Health Benefits of Diosgenin
There are so many Health Benefits of Diosgenin, such as Antitumor,Antithrombotic, Anti-inflammatory and so on, here we will browes some of its important Health Benefits as below:
Antitumor Effect
A large number of studies have shown that diosgenin has good anti-tumor activity and cytotoxicity to a variety of tumor cells, including breast cancer cells, colon cancer cells, prostate cancer cells, liver cancer cells, lung cancer cells, gastric cancer cells, oral cancer cells, skin cancer cells, osteosarcoma cells, etc. Diosgenin can promote specific and non-specific cellular immune response, inhibit tumor cell proliferation, induce tumor cell apoptosis, block cell cycle and prevent tumor metastasis through immune regulation. In conclusion, diosgenin plays an anti-tumor role by regulating a variety of cell signaling pathways, and is closely related to many important molecular targets such as growth, differentiation, apoptosis, and tumor formation.
Antithrombotic Effect
Blood clots are small patches of blood flow formed on the surface of the inner surface of the blood vessels of the cardiovascular system, which are composed of insoluble fibrin, deposited platelets, and accumulated white and red blood cells. NO is an important cellular messenger molecule in vivo, which is closely related to platelet adhesion and inflammatory response. Diosgenin can inhibit platelet aggregation, reduce myocardial infarction area and whole blood viscosity by increasing serum NO, so as to achieve antithrombotic effect. It has been found that sapogenin can decrease serum creatine kinase (CK) and lactate dehydrogenase (LDH) levels, significantly inhibit the increase of plasma thromboxane (TXB2) induced by myocardial ischemia, and prolong the time of thrombosis.
Anti-inflammatory Effect
Recent studies have identified the role of diosgenin in inflammatory cells. Studies have shown that diosgenin can regulate the expression of vascular endothelial growth factor (VEGF) by inhibiting the regulation of two subunits of activated protein-1 (AP-1) in rat synovial cells, thereby reducing angiogenesis and inflammatory response. In addition, diosgenin inhibited the expression of IL-1β-induced inflammatory mediators. Moreover, a recent study also reported that diosgenin can inhibit the proliferation and migration of RA synovial cells and reduce the inflammatory response of RA synovial cells by down-regulating phosphodiesterase 3B (PDE3B). Importantly, diosgenin can also reduce MPO levels and reduce inflammatory responses by inhibiting the release of inflammatory mediators and neutrophil infiltration.
Diosgenin Side Effects
Taking diosgenin may cause gastrointestinal discomfort, such as nausea, vomiting, bloating, abdominal pain, diarrhea and other adverse reactions. Sometimes liver function damage can occur, and some people may also have allergic reactions such as rashes and itching. If a few people have more serious allergic reactions such as breathing difficulties, they should immediately stop taking the drug and go to a nearby hospital in time. Therefore, please use diosgenin under the guidance of a doctor or pharmacist, in case of allergic reaction, please seek medical attention immediately.
Where to Buy High Quality Diosgenin
Henan Steeda Industrial Co.,Ltd is a Reputed Manufacturer and Supplier Supplying High Quality Pharmaceutical, Nutraceutical and Cosmeceutical Ingredients. Diosgenin is one of our most competitive ingredients with stocks available all year round. By providing high quality, we establish long-term relationships with our customers.
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Product Name | Diosgenin |
CAS Number | 56786-63-1 |
Molecular Formula | C27H42O3 |
Country of Origin | China |
Appearance | Powder |
GMO Status | NON-GMO |
Allergen | Allergen Free |
Sterilization | Non-Irradiated |
Grade | Could Meet Pharma Grade, Food Grade, Cosmetic Grade and Feed Grade |
Shelf Life | 2 Years if Sealed and Store away from Direct Sun Light |