Equol

Equol Reviews

Equol (3-(4-Hydroxyphenyl)-7-chromanol), an isoflavandiol estrogen metabolized from soy isoflavones, daidzin, and daidzein, is produced by intestinal bacteria of 30–50% human. And Daidzein is a type of isoflavone found in soybeans and other plant sources. Equol was first isolated from pregnant mare in 1932, and the name was suggested by this equine connection. Equol is a compound that can exist in two mirror forms, called enantiomers: (S) – Equol and (R) – Eqool. (S) – equol is produced in humans and animals and has the ability to metabolize soy isoflavones and daidzein, while (R) – equol can be chemically synthesized. People use equol to treat menopausal symptoms. It is also used for aging skin, diabetes, osteoporosis, breast cancer and many other diseases, but there is no good scientific evidence to support these other uses.

How Equol Works

It is known that the effective components of daidzein are mostly glycosidic bound and difficult to be digested and absorbed by the gastrointestinal tract. How is its extremely low bioavailability (less than 5%) and extremely high estrogenic effect (superior to estrogen) formed? Research has found that the interaction between the glycosidic components of daidzein and the gut microbiota can produce a novel microbial transformation product, equol, which has significantly improved biological activity and bioavailability. Equol is a highly estrogenic binary phenol. On the one hand, daidzein directly enters the gut as a microbial culture medium, which not only provides nutrients for the gut microbiota, promotes the colonization and proliferation of the gut microbiota, but also maintains the stability of the gut microbiota; On the other hand, glycoside hydrolases secreted by gut probiotics such as bifidobacteria and lactobacilli catalyze the conversion of daidzein into equol.

Health Benefits of Equol

There are so many Health Benefits of Equol, Similar Effect as Predniso, Antioxidant, Reduce Skin Inflammation, Other Health Functions, here we will browes some of its important Health Benefits as below:
Similar Effect as Predniso
Equol is a metabolite of soy isoflavones and a plant estrogen. Breast cancer, atherosclerosis, osteoporosis and other diseases are all related to female estrogen deficiency, and equol can play the role of estrogen and bind to ER receptor, thereby inhibiting related diseases caused by estrogen imbalance. In addition, because androgens can promote the growth of prostate cancer cells, and the estrogenic effect of equol in male animals is manifested as an anti androgenic effect, estrol also has a certain anti-cancer effect.
Antioxidant
Equol belongs to the polyphenolic class and can act as a hydrogen/electron acceptor to scavenge free radicals. In vitro studies have shown that it also has chemical and biological properties and is a strong antioxidant that can bind to specific androgens 5α- Dihydrotetosterone. Moreover, compared to genistein, vitamin C, or other polyphenolic compounds such as quercetin, it has a stronger ability to neutralize oxidants. In addition, equol can increase Nrf2 levels and bind to estrogen responsive element (EREs) Nrf2 genes, increasing the expression of other antioxidant genes.
Reduce Skin Inflammation
The immunoprotective effect of equol is related to its antioxidant effect. The application of equol has an immunoprotective effect on the skin, as it not only activates the estrogen receptor signaling pathway of the skin, but also induces the protective effect of endogenous skin antioxidant enzyme heme oxygenase (HO). In addition, the pro-inflammatory transcription factor NF kappB (NF KB) exists in all cell types and is involved in the expression of many genes involved in oxidative stress mechanisms, such as cytokines, which play an important role in inflammatory diseases. And it has been proven that equol can inhibit NF-KB in macrophages and prevent the production of free radicals such as nitric oxide (NO), thereby reducing the occurrence of inflammation.
Other Health Functions
Numerous studies in the field of human medicine have shown that equol has a certain effect on the prevention and treatment of tumors and cardiovascular diseases. (R) – Equol and (S) – Equol can inhibit the proliferation of human breast cancer MDA-MB-231 cells by down regulating the expression of matrix metalloproteinase-2 (MMP-2). Equol has an inhibitory effect on skin cancer induced by ultraviolet radiation or 7,12-xylene anthracene (DMBA).

Equol Side Effects

Eating Equol may be safe for a year. It can cause some minor side effects, such as constipation and bloating.

Where to Buy High Quality Equol

Henan Steeda Industrial Co.,Ltd is a Reputed Manufacturer and Supplier Supplying High Quality Pharmaceutical, Nutraceutical and Cosmeceutical Ingredients. Equol is one of our most competitive ingredients with stocks available all year round. By providing high quality, we establish long-term relationships with our customers.

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