Fermented GABA (Gamma-Aminobutyric Acid)

Fermented GABA (Gamma-Aminobutyric Acid) Reviews

Gamma-Aminobutyric Acid (GABA) also known as γ- Aminobutyric acid，4-aminobutyric acid, 4-AB, aminobutyric acid, and piperidine acid. GABA is a white or nearly white crystalline powder that is soluble in water, slightly soluble in ethanol and acetone, and insoluble in benzene and ether. GABA is an amino acid widely distributed in animals, plants, and microorganisms. Plants such as beans, algae, ferns, mosses, and ginseng all contain GABA in their seeds, rhizomes, and tissue fluids. In animals, GABA is almost exclusively present in nerve tissue, with the highest concentration occurring in the substantia nigra of the brain. GABA is an important inhibitory neurotransmitter in the central nervous system, which participates in various metabolic activities and has high physiological activity. Research has shown that GABA has the effects of improving sleep quality, lowering blood pressure, antioxidation, and anti-aging, and is mainly used in the fields of medicine, food, and cosmetics.

How Does Fermented GABA (Gamma-Aminobutyric Acid) Works

The process of action of GABA is actually the process of action of neurotransmitters. GABA, as an inhibitory neurotransmitter, acts on excitatory nerves. When it binds to receptors on excitatory synapses, the neuron is unable to release neurotransmitters to the next neuron before branching, interrupting signal transmission between nerves, thereby achieving the effects of inhibiting excitement, calming emotions, and promoting sleep.

Health Benefits of Fermented GABA (Gamma-Aminobutyric Acid)

There are so many Health Benefits of Fermented GABA (Gamma-Aminobutyric Acid), such as Immune Regulatory Function, Lowering Blood Pressure, Treating Diabetes, Improving Cognitive Function and so on, here we will browes some of its important Health Benefits as below:
Immune Regulatory Function
GABA also has immune regulatory functions. GABA can significantly inhibit the growth of cytokine induced killer cells (CIK), reduce the expression of surface molecules CD28 and CD25 on CIK cells, and promote cell apoptosis.
Lowering Blood Pressure
GABA also has a certain blood pressure lowering effect, which can be achieved by dilating blood vessels and inhibiting the activity of angiotensin converting enzyme (ACE) to lower blood pressure. The binding of GABA to postsynaptic receptors can effectively promote vasodilation, thereby lowering blood pressure.
Treating Diabetes
GABA stimulates the pancreas β cell proliferation by activating GABA receptors on the pancreatic cell membrane, thus promoting insulin secretion and inhibiting glucagon secretion, increasing insulin sensitivity, maintaining glucose homeostasis, and also directly or indirectly exerting anti-inflammatory effects. GABA plays an active role in the intervention of diabetes.
Improving Cognitive Function
Measurement of GABA levels in the medial parietal lobe of patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI) revealed: The level of GABA is negatively correlated with cognitive functions such as hearing and memory. Compared with MCI patients, GABA levels are higher in AD patients. Therefore, GABA has potential beneficial effects in the treatment of AD patients.
Antiepileptic
The imbalance between GABA inhibitory neurotransmitters and Glu excitatory neurotransmitters is considered one of the main mechanisms of epileptic seizures. GABA levels in the spinal fluid of epileptic patients are significantly lower than those in normal individuals, and their levels are related to the type of seizure. Supplementing GABA has varying degrees of therapeutic effects on epilepsy patients, especially on children, adolescents, and mild patients. It can also alleviate symptoms in severe and refractory pain patients.
Detoxification Effect
GABA can interact with α- Ketoglutamic acid reacts to generate glutamic acid, inhibiting the decarboxylation reaction of glutamic acid, effectively reducing blood ammonia concentration, and promoting more glutamic acid to combine with ammonia to produce urea for excretion from the body, relieving ammonia toxicity and improving liver function. Numerous studies have shown that alcohol has neurotoxicity and has a significant impact on the morphology and biochemical properties of osteoblasts. Spoerri et al. found that GABA can alleviate the toxicity of alcohol on neurocytes, maintain the phenotype of neurocytes, and have a neurotrophic effect.
Regulating Reproductive Function
GABA is also present in male gonads and accessory glands, closely related to sperm motility and steroid hormone production, and has a regulatory effect on male reproductive function. Research has found that there are GABA receptors on the surface of sperm membranes, indicating a certain relationship between GABA and sperm function. GABA can induce acrosome reaction in human capacitated sperm, and it significantly increases with the process of sperm capacitation, with a clear dose-response relationship. This effect can be enhanced by P4. In addition, GABA can significantly promote the ability of human sperm to penetrate eggs.
Improving Sleep Function
GABA is a natural brain sedative that can also have a calming effect, improving sleep quality. This is mainly because GABA synthesis neurons are distributed in the brainstem, nuclei of the diencephalon, and projection neurons, playing an inhibitory role in cortical projection. Moreover, Li Shaodan et al. explored the changes in neurotransmitter activity in the brain of individuals with sub healthy insomnia and concluded that: Sub healthy insomnia is mainly caused by abnormal activity of GABA and Glu. Other studies have shown that compared to the control group, the GABA intake group is more likely to fall asleep and has a higher level of deep sleep.
Antianxiety
GABA plays an important role in improving stress and emotional disorders. Intake of GABA can increase the activity of glucose phospholipase, thereby promoting energy metabolism in the brain, increasing cerebral blood flow and oxygen supply, and improving neurological function. Furthermore, it can improve the situation of excessive emotional fluctuations and alleviate anxiety and tension.
In addition, GABA is an inhibitory neurotransmitter in the nervous system that can bind to anti anxiety brain receptors and activate them. It then works with other substances to prevent information related anxiety reaching the brain indicator center, thereby promoting relaxation and eliminating nerve tension, achieving anti stress and anti anxiety effects.

Fermented GABA (Gamma-Aminobutyric Acid) Side Effects

Normal use of GABA is safe, but excessive or frequent use of GABA related drugs can have negative effects on the human body, such as damage to multiple organs such as the liver and kidneys. Moreover, there may be some side effects such as dizziness, nausea, abdominal pain, diarrhea, etc.

Where to Buy High Quality Fermented GABA (Gamma-Aminobutyric Acid)

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