Galangin

Galangin Reviews

Galangin, also known as 3,5, 7-trihydroxyflavone, is a natural flavonol. Galangin is mainly an effective ingredient extracted from galangal, but also comes from Xerochrysum bracteatum (Ventenat) Tzvelev and propolis. Studies have found that galangin has antibacterial, anti-inflammatory, antiviral, anti-tumor, skin protection, anti-diabetes and its complications, anti-fibrosis, neuroprotection and other pharmacological activities, and its application prospects are broad. It can be used as a functional food ingredient, but also has the potential for great medicinal or nutritional uses.

How Galangin Works

Galangin can effectively inhibit TPA-induced invasion and migration of HepG2 cells through the protein kinase C/ extracellular signal-regulated kinase (PKC/ERK) pathway.

Health Benefits of Galangin

Galangin has many pharmacological activities, such as antibacterial, anti-inflammatory, antiviral basic activities are not more detailed here. The benefits and mechanisms of action of galangin in Alzheimer’s disease, breast cancer and diabetes are described in detail below.
Galangin may help improve Alzheimer’s disease
Alzheimer’s disease is a neurodegenerative disease that is more common in the elderly. The study found that the pathology of the disease includes the formation of neuritic plaques, mainly composed of amyloid β-protein (Aβ) peptides in the brain, as well as neurofibrillary tangles. Acetylcholinesterase activity is associated with the consumption of acetylcholine, which leads to memory-related problems in Alzheimer’s disease. Therefore, inhibition of acetylcholinesterase (AChE) is a possible therapeutic strategy to treat this disease. Galangin decreased autophagy by increasing phosphorylation of Akt and mTOR and improving phosphorylation of GSK3β. Both of these factors contribute to inhibiting autophagy in PC12 cells induced by Okada acid (OA). In induced memory impairment models, galangin has also been shown to improve cognitive and memory function and increase the concentration of acetylcholine.
Galangin may help inhibit breast cancer metastasis
Breast cancer is a common malignant tumor in women, which originates from uncontrolled proliferation of breast epithelial cells. Its incidence is generally 10%~30%, and it is one of the main cancers threatening women’s health. The migration and invasion of breast cancer cells play an important role in the process of cancer metastasis. Because PI3K Akt is closely related to breast cancer metastasis, PI3K Akt over activation affects the expression of multiple downstream effectors MMP-2 and MMP-9, and plays a key role in promoting proliferation, migration and invasion in breast cancer cells. Inhibiting the expression of PI3K and Akt can inhibit the migration and invasion of breast cancer cells and slow down tumor progression. In 2016, XU and YAO studied the effect and mechanism of migration and invasion of MDA-MB-231 breast cancer cells. Their research preliminarily confirmed that galangin can effectively inhibit the growth of breast cancer cell MDA-MB-231 in vivo and in vitro, and can inhibit the expression of PI3K, Akt, MMP-2, MMP-9, p-NF – κ B p65 in tumor tissue.
Galangin may help prevent and treat diabetes
Galangin significantly improved the cognitive impairment caused by diabetes, significantly reduced the level of advanced glycation end products (AGES) in the brain, significantly increased the activity and expression of beta amyloid precursor protein beta lyase 1 (BACE1) in the brain, significantly reduced the levels of interleukin-1 β (IL-1 β) and tumor necrosis factor alpha (TNF – α) in the brain, and significantly increased the level of reduced glutathione (GSH) in the brain. Significantly increase the activity of superoxide dismutase (SOD) and GSH levels in serum. Galangin can be used for the prevention and treatment of diabetes encephalopathy and other diabetes complications.

Galangin Side Effects

Generally speaking, galangin is beneficial for the health of most people, but some people may also experience side effects such as reduced appetite, excessive urination, decreased energy levels, and even coma or death.

Where to Buy High Quality Galangin

Henan Steeda Industrial Co.,Ltd is a Reputed Manufacturer and Supplier Supplying High Quality Pharmaceutical, Nutraceutical and Cosmeceutical Ingredients. Galangin is one of our most competitive ingredients with stocks available all year round. By providing high quality, we establish long-term relationships with our customers.

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