Gardenia Fruit Extract Gardenoside

What is Gardenia Fruit Extract Gardenoside

Gardenia, also known as cape jasmine, is a genus of flowering plants in the coffee family, Rubiaceae, native to the tropical and subtropical regions of Africa, Asia and Australia. Gardenia not only has ornamental value, because its fruits, flowers, leaves, roots contain a variety of chemical components, making it extremely edible and medicinal value. The most widely used part of gardenia is the fruit. The fruit is oval or oblong-oval in appearance, reddish yellow or brownish-red in surface, with winged longitudinal edges and a calyx at the top. The smell is slight, the taste is slightly sour and bitter. Gardenia extract is mainly extracted from dried and ripe fruits, containing geniposide, dehydroxygardenin, gardenia ketoside, Geniposide, geniposide, flavonoids gardenin, crocin, crocetin, ursolic acid, etc.
This article mainly introduces its component Gardenoside. Geniposide, also known as dehydroxygeniposide, geniposide, belongs to the iridoid glycoside compounds, which is extracted from the dried and ripe fruits of the rubiaceae plant gardenia. Its pure appearance is white powder, easily soluble in water, soluble in ethanol, insoluble in petroleum ether. Gardenin has a variety of uses. It can be fermented under different conditions to produce natural food coloring gardenia blue and gardenia red. It can also be used as a raw material for the treatment of cardiovascular and cerebrovascular diseases, liver and gallbladder, diabetes and other diseases.

Pharmacological Action of Gardenia Fruit Extract Gardenoside

Garminoside is a kind of iridoid glycoside with a variety of biological activities, with neuroprotection, anti-diabetes, anti-proliferation, anti-oxidation, anti-tumor, anti-inflammation, immune regulation, treatment of depression, reducing blood lipids, anti-ulcer, liver protection, gallbladder, antihypertensive, sedative, hemostatic, detumescence, and other pharmacological effects.

Health Benefits of Gardenia Fruit Extract Gardenoside

Gardenoside has been associated with an array of potential health benefits, such as Hepatoprotective Effect, Hypoglycemic and Lipid-lowering Effects and so on, here we will browes some of its important Health Benefits as below:
Hepatoprotective Effect
Gardenoside is known to have liver protective properties. On the one hand, gardenin can inhibit pain in chronic contractile injury by regulating P2X3 and P2X7 receptors. On the other hand, gardenoside has antioxidant effect, which can clear free radicals and reduce oxidative damage of liver. Therefore, gardenoside can be used to treat alcoholic hepatitis and drug-induced liver injury caused by long-term alcohol consumption or drug abuse. However, please use gardeniside under the guidance of a professional doctor to avoid excessive intake.
Hypoglycemic and Lipid-lowering Effects
Geniposide can reduce serum total cholesterol, triglyceride and low density lipoprotein cholesterol levels, increase the level of high density lipoprotein cholesterol levels, and have a certain therapeutic and preventive effect on hyperlipidemia. Moreover, some studies have found that gardenoside can significantly reduce blood glucose and improve glucose tolerance in diabetic model rats. Glucose consumption test also showed that geniposide could significantly promote glucose absorption by preadipocytes.
Antithrombotic Effect
The researchers used a bypass circulation thrombosis model and a common carotid artery thrombosis model. The results showed that gardeniside and its aglycones could significantly prolong the coagulation and bleeding time and reduce the thrombus weight of the two thrombus models. Moreover, some studies suggest that geniposide and its metabolite genipin can significantly delay the occlusion time of femoral artery thrombosis in rats and inhibit the activity of phosphatidylase, which is the mechanism of anti-platelet aggregation.
Treatment of Osteoarthritis
It was found that gardeniside can promote the proliferation of ligament fibroblasts, tissue repair and ligament healing. The clinical application shows that the application of gardenia extract on the treatment of osteoarthritis has obtained a good effect. In addition, by using the method of cultured rat chondrocytes in vitro, the researchers found that geniposide can regulate the chondrocyte cycle and promote the proliferation of chondrocytes. Other studies have also found that gardenia water extract and gardeniside can promote the proliferation of fibroblasts and collagen synthesis, which is also consistent with the clinical use of gardenia in the treatment of contusion and contusion.
Sedative Hypnosis
Gardeniside can produce sedative and hypnotic effects through the central nervous system regulation. But its sedative and hypnotic effects are still controversial. It has been found that gardeniside has no obvious effects on sleep, but the yellow hormone in gardenia have effect. Some studies have also found that high dose of gardenoside can shorten the sleep time of experimental animals and increase the sleep rate of experimental animals.
Antitumor Effect
It was found that aglycoside of gardenia can inhibit the growth of mouse leukemia P388 cells. It has anticancer effect on rat tumor model by inhibiting the carcinogenic effect of sublethal dose X-ray and reducing the damage of high intensity harmful X-ray to cells. 5-acetylgardenin inhibited the expression of phosphoinositol 3 kinase protein and the phosphorylation of extracellular signal-regulated kinases 1 and 2, and activated NF-K-β, c-Fos and c-Jun, indicating that 5-acetylgardenin could effectively inhibit tumor cell metastasis.

Gardenia Fruit Extract Gardenoside Side Effects

In general, proper use of Gardenoside has few toxic side effects. However, long-term use of Gardenoside may cause liver and kidney damage, nausea, vomiting, diarrhea and allergic reactions and other adverse reactions.

Where to Buy High Quality Gardenia Fruit Extract Gardenoside

Henan Steeda Industrial Co.,Ltd is a Reputed Manufacturer and Supplier Supplying High Quality Pharmaceutical, Nutraceutical and Cosmeceutical Ingredients. Gardenia Fruit Extract Gardenoside is one of our most competitive products with stocks available all year round. By providing superior quality, we establish long-term relationships with our clients.

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