Harmaline

Harmaline Reviews

Harmaline is a fluorescent indole alkaloid selected from Camelbumin alkaloids and β – carbaline, present in the seeds of the Tribulus family plant Camelbumin. Peganum harmala L. is a perennial herbaceous plant, and its whole plant contains alkaloids, steroids, flavonoids, anthraquinone, amino acids, and other components. Among them, there are the most types of alkaloids, mainly harmaline and harmine. Peganum harmala L. is a traditional ethnic medicine used by ethnic groups such as the Uyghur, Kazakh, and Mongolian in China. Traditionally used as a menstrual and abortion medication in the Middle East and North Africa. In countries such as Pakistan and India, its seeds are used as dyes for wool or velvet. Peganum harmala seed extract harmaline has certain effects on the central nervous system, cardiovascular system, respiratory system, immune system, muscles, uterus, etc. In addition, harmine also has pharmacological activities such as anti-tumor, insecticidal, bactericidal, anti-inflammatory, and analgesic effects.

How Harmaline Works

In addition to the effects of harmaline on DNA topoisomerases I and II during cell replication and transcription, researchers also found that harmine competes with ATP Mg, producing specific inhibitory effects on cyclin dependent kinases CDK1/cyclin B, CDK2/cyclin A, and CDK5/p25.

Health Benefits of Harmaline

Harmaline has been associated with an array of potential health benefits, such as good effects on animal organs and tissues, Anticancer, Antibacterial and so on, here we will browes some of its important Health Benefits as below:
Effects on the Central Nervous System
In animal experiments, harmaline has excitatory effects on the cortex, motor center, spinal cord, and pons, which can cause hallucinations, tremors, paroxysmal seizures, certain specific movements, and limb stiffness. Harmaline has been used to alleviate Parkinson’s disease after encephalitis, and has a brief therapeutic effect on casual movement and eye muscle stiffness. But it is ineffective for tremors, drooling, and does not produce symptoms of scopolamine like pleasure. Its mechanism of action is unclear, and it may be due to cortical excitation, which better regulates impulses and enables better control of movement.
Effects on the Cardiovascular System
Researchers have found in experiments on frogs that harmaline can inhibit isolated frog hearts, slow down heart rate, and 3 milligrams of harmine can slow down frog heart rate and increase amplitude. At this time, even adding 2 milligrams of acetylcholine does not cause cardiac arrest. In addition, harmaline can inhibit platelet aggregation caused by adenosine diphosphate, collagen, adrenaline, and arachidonic acid, and high concentrations can eliminate platelet aggregation caused by adrenaline and adenosine diphosphate.
Effects on the Respiratory System
Low concentrations of harmaline have a weak relaxation effect on the trachea of isolated guinea pigs, while high concentrations cause it to contract. It has a weak and transient antagonistic effect on histamine induced bronchospasm. Total alkaloids and duckbill alkaloids inhibit the contraction of guinea pig tracheal smooth muscle induced by acetylcholine, histamine, and potassium chloride in a dose-dependent manner. Harmaline, and harmine not only act on the Ca2+channels that are receptor dependent and valve dependent, but also bind to the muscarinic alkaline receptor, histamine H1 receptor, and β – adrenergic receptor, exerting an antispasmodic effect on tracheal smooth muscle.
The Effect on Muscles
Harmaline can relax the smooth intestinal muscles of guinea pigs in vitro, possibly directly acting on muscle fibers. Harmaline relaxes the smooth muscle of the small intestine and inhibits the Na+/Ca2+exchange system in the isolated guinea pig ileum. It is a noncompetitive inhibitor of Ca2+induced ileal contraction. Harmaline can inhibit the contraction of cecal smooth muscle in guinea pigs by inhibiting different types of Ca2+channels. Harmaline and harmine have a paralyzing effect on the skeletal muscles of frogs and a stimulating effect on the muscles of earthworms.
The Effect on the Uterus
Harmaline has a paralyzing effect on the frog uterus and can also contract the living uterus. Harmine has an overall excitatory effect on animal uterus, while it has a relaxing effect on isolated uterus with high tension. Vasicine can induce animal miscarriage, and its mechanism may be that it can cause rhythmic contractions of pregnant uterine muscles, with contractile effects similar to oxytocin and methylergometrine.
Anticancer Effect
In vivo anti-tumor experiments have shown that both harmaline and harmine have inhibitory effects on mouse liver cancer, lymphosarcoma, reticulocyte sarcoma and other tumor strains, and there is no significant toxicity. Harmaline can also inhibit the proliferation of gastric cancer cells by downregulating the expression of cyclooxygenase-2 (COX-2), but its molecular mechanism is not fully understood. Through experimental studies on the effects of harmaline on the proliferation and apoptosis of gastric cancer cells, researchers have found that harmaline may downregulate COX-2 expression through the PTEN/Akt/MDM2 signaling pathway, inhibit gastric cancer cell proliferation, and induce apoptosis. Moreover, research has found that harmaline has certain beneficial effects on liver cancer, cervical cancer, lung cancer, and thyroid cancer.
Antibacterial Effect
The chemical structure of harmaline is similar to quinoline, so it is toxic to protozoa such as amoeba and also has some anti malaria effects. The effect of camellia alkaloid on roundworms is similar to that of santonin, and it also has an inhibitory effect on bacteria (especially Gram-positive bacteria such as Bacillus subtilis and Staphylococcus aureus). It has a bactericidal effect in vitro at a ratio of 1:10000.
Other Functions
In addition to the above effects, harmaline also have insecticidal and antibacterial effects, especially against abamectin parasites, antimalarial parasites, etc. In addition, harmaline also has anti-inflammatory, analgesic, and radiation resistant effects.

Harmaline Side Effects

Taking 4 milligrams of harmaline can cause hallucinations, while high-dose administration of harmaline can cause systemic tremors and paroxysmal seizures, with short-term motor and respiratory paralysis. It can also lower body temperature in mammals. Harmaline has an excitatory effect on the cerebral cortex and spinal cord of experimental animals, causing hallucinations, tremors, and paroxysmal seizures.

Where to Buy High Quality Harmaline

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