L-5-Methyltetrahydrofolate Calcium (L-5-MTHF-Ca)

L-5-Methyltetrahydrofolate Calcium (L-5-MTHF-Ca) Reviews

L-5-Methyltetrahydrofolate Calcium (L-5-MTHF-Ca), also known as 6s-5-methyltetrahydrofolate and active folate, is a naturally occurring calcium salt of L-5-methyltetrahydrofolate (L-5-MTHF). It belongs to the folate family of vitamins, which is an active form of folate. And L-5-methyltetrahydrofolate, also known as L-methylfolate, is one of the most biologically active and functional forms of folate and is easier to absorb than regular folate. L-5-methyltetrahydrofolate acts as an enzyme cofactor in vivo, transporting C1 in methylation reactions for the biosynthesis of pyrimidine, purine, serine, and glycine, and is the only form of free folate present in human plasma and cells. L-5-methyltetrahydrofolate calcium is a pale white to yellowish solid, odorless, and water-soluble. It is mainly involved in acetic acid metabolism pathway in human body, promoting DNA synthesis, repair and growth. It can also help maintain the normal blood and nervous system function of the human body, lack of which may cause giant cell anemia, degenerative diseases of the nervous system. L-5-methyltetrahydrofolate calcium has been identified by the US FDA as a general safe substance, can be used in food additives and pharmaceutical additives, etc., can maximize the supplement of “finished” folic acid, the body can use immediately, without any metabolism.

How L-5-Methyltetrahydrofolate Calcium (L-5-MTHF-Ca) Works

The biochemical pathway of bioactive folate involves a series of enzymatic reactions and cofactors. Absorbed folic acid is reduced and methylated to 5-MTHF during intestinal mucosal cell metabolism. This transformation is limited and does not alter folic acid as it appears in the blood circulation, and the methionine is subsequently converted to S-adenosylmethionine (SAMe), with the methyl donor involved in a number of biochemical processes. It can also participate as a donor in nucleotide synthesis, supporting biosynthesis of DNA.

Health Benefits of L-5-Methyltetrahydrofolate Calcium (L-5-MTHF-Ca)

L-5-Methyltetrahydrofolate Calcium has been associated with an array of potential health benefits, such as Promoting Fetal Development, Beneficial for Female Reproductive Health and Cardiovascular Health, Prevention and Treatment of Anemia and so on, here we will browes some of its important Health Benefits as below:
Promoting Fetal Development
Folic acid is an important nutrient that participates in the synthesis of DNA and RNA in the body, promoting cell division and growth, and is crucial for the normal development and health of embryos. Lack of folic acid may lead to fetal neural tube defects (NTDs), causing diseases such as spina bifida, cleft lip and palate, and megaloblastic anemia. L-5-methyltetrahydrofolate calcium is an active form of folate, which has advantages such as stability, high bioavailability, and no upper tolerance limit. It can more easily cross the cell membrane, provide the necessary folate for the embryo, reduce the risk of fetal disease, and help prevent the risk of fetal and placental dysplasia.
Beneficial for Female Reproductive Health
In addition to promoting fetal development, L-5-methyltetrahydrofolate calcium, as a form of active folate, is also essential for the health of the female reproductive system. Regular consumption of active folic acid can help women regulate the vitality of reproductive cells in the body, which can also improve women’s chances of conception. It can also help regulate the metabolism of estrogen and maintain the normal operation of the menstrual cycle. In addition, some studies have shown that appropriate folic acid intake has the potential to reduce the risk of reproductive health problems in women, such as polycystic ovary syndrome (PCOS).
Beneficial for Cardiovascular Health
In addition to preventing anemia, L-5-methyltetrahydrofolate calcium is also thought to be associated with cardiovascular health. Elevated homocysteine levels are associated with atherosclerosis and thrombosis, and active folic acid can help reduce homocysteine levels and promote blood circulation, so it has the effect of reducing the probability of cardiovascular disease and preventing cardiovascular disease.
Prevention and Treatment of Anemia
Active folate is a water-soluble vitamin, which is mainly involved in amino acid metabolism and promotes hemoglobin synthesis in the human body, so L-5-methyltetrahydrofolate calcium also has the effect of preventing anemia. Patients in daily life can properly eat foods rich in folic acid, such as spinach, oranges, etc., can help prevent and improve anemia symptoms.

L-5-Methyltetrahydrofolate Calcium (L-5-MTHF-Ca) Side Effects

Active folic acid usually refers to L-5-methyltetrahydrofolate calcium, although folic acid is a vitamin needed by the body, but excessive consumption of folic acid may cause gastrointestinal discomfort, allergic reactions, yellow urine, skin itching, nervous system reactions and other side effects. And while taking active folic acid, it may have an impact on the efficacy of other medications, for example, it may affect the efficacy of some anti-epileptic drugs. Therefore, when supplementing with active folic acid, it is recommended to follow your doctor’s advice and guidance to ensure moderate intake and avoid excess. At the same time, if you have any discomfort or abnormal reaction, you should seek medical attention promptly and inform your doctor about the active folic acid you are taking.

Where to Buy High Quality L-5-Methyltetrahydrofolate Calcium (L-5-MTHF-Ca)

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