Nicotinamide Adenine Dinucleotide, Reduced Disodium Salt Hydrate (NADH)

Nicotinamide Adenine Dinucleotide, Reduced Disodium Salt Hydrate (NADH) Reviews

NADH (Nicotinamide adenine dinucleotide) is a chemical substance that is the reduced state of nicotinamide adenine dinucleotide, a reduced coenzyme I. N refers to niacinamide, A refers to adenine, D is a dinucleotide. NADH and NAD+are a pair of redox pairs in cells, NADH is the reducing form of coenzyme NAD+, NAD+is its oxidized form. In redox reactions, NADH serves as a donor of hydrogen and electrons, NAD+, as a receptor for hydrogen and electrons, participates in physiological processes such as respiration, photosynthesis, and alcohol metabolism. They participate in life activities as coenzymes for many oxidation-reduction reactions in organisms and transform into each other. NADH and NMN are both outstanding in the field of anti-aging, but NADH absorbs and converts NAD+4 times higher than NMN, which has great potential in realizing human longevity.

How Nicotinamide Adenine Dinucleotide, Reduced Disodium Salt Hydrate (NADH) Works

NADH enters the human body and directly decomposes into NAD+and hydrogen (H), while releasing a certain amount of energy (ATP), which synergistically plays a role in delaying aging. In fact, the anti-aging function of NADH mainly comes from its decomposition product NAD+, NAD+is an active substance that truly participates in thousands of important physiological reactions such as cellular metabolism, redox reactions, and protein transcription. However, as NAD+is a large molecule that is difficult to be directly absorbed and utilized by cells through the cell membrane, it is usually enhanced by supplementing NMN and NADH with NAD+precursor substances to achieve anti-aging effects.

Health Benefits of Nicotinamide Adenine Dinucleotide, Reduced Disodium Salt Hydrate (NADH)

NADH has been associated with an array of potential health benefits, such as Boosting Energy, Antioxidant, Promoting Neurotransmitter Synthesis, Repairing Cell and so on, here we will browes some of its important Health Benefits as below:
Boosting Energy
NADH is not only an important coenzyme in aerobic respiration, NADH also carries a large amount of energy. The vast majority of physiological processes in cells, such as protein synthesis DNA repair, insulin synthesis and secretion, immune response, cell division, etc. require the energy molecule ATP to drive. The production process of ATP requires sufficient NADH support. Research has confirmed that extracellular use of NADH can promote an increase in intracellular ATP levels, indicating that NADH can penetrate cell membranes and increase intracellular energy levels. That is to say, cells can use exogenous supplementation of NADH to increase their energy levels. Exogenous supplementation of NADH can help restore physical strength, enhance appetite, reduce anxiety and psychological stress. And the increase in brain energy levels by NADH also helps improve mental state and sleep quality. NADH has been applied abroad in areas such as improving chronic fatigue syndrome, enhancing exercise endurance, and reducing time difference.
Antioxidant
NADH is the most powerful antioxidant in mitochondria, because NADH itself has a reducing effect and can directly remove some free radicals. In addition, NADH can regenerate oxidized coenzyme Q10, glutathione, etc., so that they can restore antioxidant capacity. In addition, NADH can also be converted by enzymes into other forms such as NAD+ and NADPH, which can activate other antioxidant pathways within the cell. Experiments have shown that NADH is more durable than vitamin C against the oxidation of LDL. In addition, NADH removes hydrogen peroxide from nerve cells, helping to prevent neurodegenerative diseases.
Promoting Neurotransmitter Synthesis
Studies have found that NADH promotes the synthesis of the neurotransmitters like dopamine, serotonin and norepinephrine.
Dopamine is the most abundant catecholamine neurotransmitter in the brain. When the concentration of dopamine in the brain decreases, the central excitation is weakened, and the ability to control muscles is lost, which can seriously cause the patient’s hands and feet to vibrate involuntarily or lead to Parkinson’s disease. In addition, lack of dopamine may cause Alzheimer’s disease, myocardial infarction and other diseases. Serotonin, also known as 5-hydroxytryptamine (5-HT), is a neurotransmitter in the brain that transmits happiness and stable mood. Serotonin affects appetite, drive (appetite, sleep, sex), and mood, and chronically low levels of serotonin can cause conditions such as obsessive-compulsive disorder, chronic fatigue syndrome, arthritis, fibromyalgia, and hypomania depression. Norepinephrine is mainly secreted by the adrenal medulla, and usually plays a role in constricting blood vessels, increasing heart rate, and dilating bronchus. The dopamine, serotonin and norepinephrine in the brain of depressed patients are in a low concentration state, and restoring their concentration clinically helps to improve people’s depressed mood. NADH as a new type of biological antidepressant, more than 90% of depression patients reported a good clinical effect.
Repairing Cell
NADH is oxidized to NAD+ after releasing biohydrogen to fuel ATP synthesis, replenishing the cellular NAD+ reservoir. As the only coenzyme of DNA repair enzyme PARP1, NAD+ is an essential substance involved in DNA repair. DNA damage and repair occur in cells all the time, and timely repair of DNA damage can prevent further cell damage and dysfunction. When people get older, there will be more and more DNA damage, and the NAD+ level in the human body will decrease, and the DNA damage will gradually accumulate, which will lead to the damage of cell structure and function, and the damage of a large number of cells will lead to the decline of tissue and organ function, and eventually cause human aging and disease, and even cancer. Studies have found that NADH can reduce the oxidative stress of cells caused by radiation, drugs, toxic substances, intense exercise, ischemia and other factors, so as to protect vascular endothelial cells, liver cells, cardiomyocytes, fibroblasts, neurons and so on.

Nicotinamide Adenine Dinucleotide, Reduced Disodium Salt Hydrate (NADH) Side Effects

When taken in moderation, NADH supplements have few side effects. But when used in excess, NADH can cause nervous tension, anxiety, and insomnia. If administered by injection, NADH may cause pain, swelling, and redness at the injection site. Few studies have investigated the long-term safety of NADH.

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