Oleoylethanolamide

Oleoylethanolamide Reviews

Oleoylethanolamide (OEA) is an endogenous peroxisome proliferator-activated receptor alpha (PPAR-α) agonist, which plays an important role in the treatment of obesity and arteriosclerosis. It is a naturally occurring ethanolamide lipid produced by the small intestine after feeding, which can regulate the feeding and weight of vertebrates. It is also a relatively short monounsaturated analogue of endogenous cannabinoid Anadamine, but unlike Anadamine, it operates independently of the cannabinoid pathway and regulates PPAR- α Active to stimulate lipolysis.

How Oleoylethanolamide Works

Oleoylethanolamide (OEA) is a lipid mediator that helps control various biological functions, such as food intake. It can regulate gene expression in the small intestine. Oleoylethanolamide can trigger the production of various receptors, such as type 1 cannabinoid receptor (CB1), peroxisome proliferator activated receptor (PPAR), and G protein coupled receptor 119 (GPR119).

Health Benefits of Oleoylethanolamide

There are so many Health Benefits of Oleoylethanolamide, including Anti-inflammatory Effect, Improving Neurological Function and Weight Loss Benefits, here we will browes some of its important Health Benefits as below:
Anti-inflammatory Effect
Scientific experiments have shown that oleoylethanolamide can inhibit the activation of NF-xB, phosphorylation of ERK1/2 and STAT3, and expression of AP-1 in LPS induced THP-1 cells. After adding ERK1/2 blockers, the inhibitory effect of oleoylethanolamide on ERK1/2 and STAT3 phosphorylation was weakened, while the inhibitory effect on AP-1 and I-6 expression was also reduced.
This experiment indicates that in LPS induced THP-1 cells, oleoylethanolamide exerts anti-inflammatory effects by inhibiting the NF-KB downstream of TLR4 and the ERK1/2/AP-1/STAT3 signaling pathway, which indirectly confirms the anti-inflammatory effect of oleoylethanolamide.
Improving Neurological Function
Through the study of oleoylethanolamide on the motor function of rats after cerebral ischemia, it was found that oleoylethanolamide can significantly improve the motor function of rats after cerebral ischemia at different time points, and can increase the number of newly generated neurons and neovascular cells in the ischemic penumbra, as well as VEGF/SDF-1/CXCR4, DCX, GAP-43/SYNBDNF/NGF/NT3Wnt3a/p- β- Catenin/ β- Expression of catenin and p-CREB/t-CREB. Furthermore, the experimental conclusion is drawn that oleoylethanolamide can improve neurological function after cerebral ischemia by promoting the reconstruction of the neurovascular network in the ischemic penumbra of the cortical area after stroke.
Weight Loss Benefits
Oleoylethanolamide may be used as a weight loss supplement to burn fat, but there is currently insufficient evidence to suggest that oral oleoylethanolamide supplements can burn fat. The mechanism of its weight loss operation is that oleoylethanolamide acts on a receptor called peroxisome proliferator activated receptor α (PPAR) α. When this receptor is activated in the intestines of rats, the amount of food consumed by the animals decreases. Studies on rats have shown that both injection and oral administration of oleoylethanolamide can reliably reduce food intake. A small amount of evidence suggests that oleoylethanolamide may be able to act on PPAR α to help with fat loss. When this receptor is activated in adipose tissue, energy expenditure increases.

Oleoylethanolamide Side Effects

There is currently insufficient evidence to prove that oleoylethanolamide have strong side effects.

Where to Buy High Quality Oleoylethanolamide

Henan Steeda Industrial Co.,Ltd is a Reputed Manufacturer and Supplier Supplying High Quality Pharmaceutical, Nutraceutical and Cosmeceutical Ingredients. Oleoylethanolamide is one of our most competitive ingredients with stocks available all year round. By providing high quality, we establish long-term relationships with our customers.

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