Palmitoylethanolamide

Palmitoylethanolamide Reviews

Palmitoylethanolamide (PEA) is an endogenous fatty acid amide, belonging to the class of nuclear factor agonists. It is a fatty substance produced in the human body and also found in animal organs, egg yolks, olive oil, safflower, soy lecithin, peanuts, and other foods. It is a natural analgesic with endogenous analgesic and anti-inflammatory effects, and is effective for both acute and chronic pain. Its mechanism of action is to bind to receptors (nuclear receptors) in the nucleus, and then exert various biological functions related to chronic pain and inflammation. Palmitoylethanolamide (PEA) is widely used in sports nutrition supplements and combination health formulas around the world, especially in EU countries such as the United States, Australia, the United Kingdom, Canada, and the Netherlands, Belgium, Italy.

How Palmitoylethanolamide Works

Palmitoylethanolamide (PEA) is technically referred to as a lipid signaling molecule that promotes resolution, meaning that PEA affects the central control mechanism within cells, thereby addressing inflammation and cellular stress.

Health Benefits of Palmitoylethanolamide

There are so many Health Benefits of Palmitoylethanolamide, including Anti-inflammatory Effect, Analgesic Effect, Antidepressant Effect and Weight Loss Effect, here we will browes some of its important Health Benefits as below:
Anti-inflammatory Effect
PEA may help reduce the production of inflammatory substances. On the one hand, PEA mainly exerts anti-inflammatory effects by affecting immune cells that control inflammation, especially those in the brain. On the other hand, PPAR-a plays a role. PPAR-a is mainly distributed in some organs and tissues with active fat catabolism, and is the main transcriptional regulator of fatty acid oxidase gene. It is involved in regulating the uptake and oxidation of lipids, and the metabolism of amino acids. From a macro perspective, PPAR-a can participate in a variety of pharmacological and physiological processes such as hemostasis, inflammatory reaction, lipid metabolism disorder, atherosclerosis and coronary heart disease.
Analgesic Effect
PEA mainly acts on receptors on cells, which control various aspects of cell function. These receptors are called PPARs. PEA and other compounds that help activate PPAR can alleviate pain. The mechanism of action and efficacy of PEA have been further validated in animal experiments of chronic pain and chronic inflammation models. In a chronic granulomatous inflammation model, PEA can prevent mechanical pain caused by nerve formation and sprouting. In cystitis, PEA can alleviate pain caused by visceral nerve reflex hyperactivity.
Antidepressant Effect
PEA may not only help alleviate brain inflammation, but also have an impact on other brain related issues. That is to say, PEA has a well-established mechanism that plays a crucial role in chronic pain, mental function, and depression. Numerous pieces of evidence indicate that PEA plays a significant role in alleviating depression caused by decreased cognitive abilities and chronic pain. Both animal models of depression and double-blind placebo-controlled trials in humans have shown antidepressant effects. Research has shown that PEA can help alleviate stress responses, thereby playing an important protective role in resisting stress and anxiety.
Weight Loss Effect
In addition to its anti-inflammatory, analgesic, and antidepressant effects, PEA can also promote metabolism, reduce serum triglycerides, increase serum high-density lipoprotein cholesterol, improve blood sugar control, and help reduce weight by consuming fat.

Palmitoylethanolamide Side Effects

Palmitoylethanolamide (PEA) is generally considered safe, and without adverse drug reactions (ADRs) or drug interactions.

Where to Buy High Quality Palmitoylethanolamide

Henan Steeda Industrial Co.,Ltd is a Reputed Manufacturer and Supplier Supplying High Quality Pharmaceutical, Nutraceutical and Cosmeceutical Ingredients. Palmitoylethanolamide is one of our most competitive ingredients with stocks available all year round. By providing high quality, we establish long-term relationships with our customers.

Our Service

1) Payment
We accept payments through Telex Transfer, PayPal, Western Union, Letter of Credit, MoneyGram.
2) Shipping method
We offer several delivery services to suit all customer needs, such as AIR freight, DHL, FEDEX, TNT, UPS, EMS, SEA freight and others.
3) Lead time
Usually orders can be dispatched within 3 workdays by courier; 15-30 workdays by Sea.
4) Guarantee
We offer a 60 Days 100% Risk Free Guarantee for any orders. We will refund your money if our products do not meet your requirements.