Reserpine

Reserpine Reviews

Reserpine, also known as Serpentine, is an indole alkaloid drug used for the treatment of hypertension and mental illness. It was originally extracted from the rauvolfia serpentina. Reserpine is a monoamine neurotransmitter that mainly inhibits sympathetic nervous system, reduces myocardial contractility and heart rate, and regulates peripheral resistance to lower blood pressure and other effects. Reserpine is a relatively ancient antihypertensive drug that mainly depletes the neurotransmitters of dopamine in the brain, achieving a hypotensive effect.

How Reserpine Works

Reserpine works by blocking the vesicular monoamine transporter VMAT, which typically transports free norepinephrine, serotonin, and dopamine from the cytoplasm of the presynaptic nerve to the vesicles and then releases them into the synaptic gap. Unprotected neurotransmitters are subsequently metabolized by MAO and therefore never reach the synapse.

Health Benefits of Reserpine

The main benefits of reserpine are Lowering Blood Pressure, Relieveing Arrhythmia and Antianxiety, here we will browes these three important Health Benefits as below:
Lowering Blood Pressure
Reserpine is an adrenergic neuron blocking antihypertensive drug. It can prevent the composition of mediators within the adrenergic nerve endings and deplete the mediators with pressor effects in the vesicles. It mainly reduces blood pressure by consuming the peripheral sympathetic nerve endings adrenaline, catecholamines and serotonin in tissues such as the heart and brain.
Relieveing Arrhythmia
Reserpine can block the β 1 adrenergic receptors in the heart, slowing down heart rate. It can also reduce the occurrence of arrhythmias by reducing myocardial oxygen consumption. Therefore, reserpine can be used to treat arrhythmias.
Antianxiety
Reserpine can block the presynaptic dopamine receptors in the central system, reducing dopamine receptors in the brain and alleviating anxiety. In addition, reserpine can also reduce myocardial oxygen consumption and improve myocardial ischemia, so reserpine can be used to treat anxiety.

Reserpine Side Effects

The biggest side effect of reserpine is orthostatic hypotension. This is because it exhausts the neurotransmitters that regulate blood pressure. Once there is a shift in position, the adjustment of blood pressure becomes significantly sluggish, leading to orthostatic hypotension. Another side effect of it is depression, as it depletes the brain’s serotonin and dopamine, and previous use can lead to more patients experiencing depression. In addition, reserpine may also have side effects such as nausea, vomiting, dizziness, drowsiness, unease, fatigue, etc. Currently, reserpine is rarely used alone, and more advanced calcium antagonists, ARB, or composite preparations are used to replace reserpine.

Where to Buy High Quality Reserpine

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