Tangerine Peel Extract Hesperetin

What is Tangerine Peel Extract Hesperetin

The tangerine is a type of citrus fruit that is orange in color. Hesperetin extracted from Tangerine Peel is a chemical substance belonging to dihydroflavones. Its chemical structure includes a benzene ring and a pyrrole ring, with hydroxyl and methoxy groups attached to the benzene ring. Its appearance is light yellow needle shaped crystals or powder. It mainly comes from the hydrolysis of Hesperidin and has strong biological and pharmacological activities, mainly manifested in antioxidant, anti-inflammatory, lipid-lowering, cardiovascular protection, widely used in organic chemistry, medicine, food, health products, cosmetics and other fields.

How Tangerine Peel Extract Hesperetin Works

The mechanism of hesperetin mainly comes from its anti-inflammatory activity, oxidative stress response, apoptosis mechanism, cell cycle, STAT3, PI3K/AKT pathway, angiogenesis, etc.
Hesperetin inhibits the production of nitrogen dioxide, prostaglandin E2 (PGE2), and the expression of nitric oxide synthase (iNOS) protein.
Oxidative stress is associated with the development of various diseases, including cancer, and hesperetin can reduce the production of free radicals and oxidative stress, thus limiting the pathogenesis.
Apoptosis is a key mechanism for the development and strict regulation of cell death. Natural products or bioactive molecules, including hesperetin, have been shown to be associated with cancer management by inducing cell apoptosis.
Hesperetin can prevent the progression of the conventional cell cycle in human osteosarcoma MG-63 cell line.
STAT3 is associated with the regulation of various important biological processes, such as cell proliferation, angiogenesis, invasion, differentiation, apoptosis, inflammation and metastasis.

Health Benefits of Tangerine Peel Extract Hesperetin

Hesperetin has been associated with an array of potential health benefits, such as Antioxidant, Anti-inflammatory, Hypolipidemic, Cardiovascular Protection, Antitumor and so on, here we will browes some of its important Health Benefits as below:
Antioxidant Effect
Hesperidin has strong antioxidant capacity, even stronger than vitamin C and vitamin E. It can eliminate peroxynitrite ions and avoid the harm caused by peroxidation reactions.
Anti-inflammatory Effect
Hesperetin can inhibit the production and release of inflammatory factors, thereby reducing the inflammatory response. Research has found that hesperetin can inhibit some inflammation related signaling pathways, such as NF-KB, MAPK, etc. Compared with hesperidin, hesperidin has stronger anti-inflammatory effects.
Hypolipidemic Effect
Hesperetin can reduce the levels of cholesterol and triglycerides in the blood, mainly by inhibiting the action of cholesterol producing and esterifying enzymes, thereby promoting cholesterol metabolism and excretion, and achieving the effect of lowering blood lipids.
Cardiovascular Protection
Hesperetin has the effect of reducing blood lipids and vascular permeability, and can prevent thrombosis. Hesperetin can also protect endothelial tissue from hypoxia by stimulating certain mitochondrial enzymes such as succinate dehydrogenase, preventing coagulation caused by endothelial cell necrosis and inducing thrombosis. In addition, hesperetin promotes antiplatelet coagulation activity by inhibiting the phosphorylation of PLC γ 2 and its downstream signaling, which can prevent thrombus formation and benefit the cardiovascular system.
Antitumor Effect
Hesperidin has antioxidant properties, which can prevent cancer caused by genetic changes caused by antioxidants. Research has found that hesperetin can regulate the expression levels of death related proteins in lung cancer cells, induce cancer cell apoptosis, and thus achieve anti-tumor effects. In addition, hesperetin can inhibit the expression of programmed cell death ligand 1 (PD-L1) by inactivating STAT1 and STAT3 signaling molecules, thereby utilizing its anti-cancer properties against oral cancer cells. In summary, the anticancer potential of hesperetin has been confirmed by regulating inflammation, cell cycle arrest, apoptosis, angiogenesis, and cell signaling pathways.

Tangerine Peel Extract Hesperetin Side Effects

Hesperidin is a natural compound that does not accumulate in any organ and is safe to use with no significant side effects. Current research indicates that hesperetin does not have significant toxic side effects at appropriate doses, but further research is needed for special populations such as pregnant women and children.

Where to Buy High Quality Tangerine Peel Extract Hesperetin

Henan Steeda Industrial Co.,Ltd is a Reputed Manufacturer and Supplier Supplying High Quality Pharmaceutical, Nutraceutical and Cosmeceutical Ingredients. Tangerine Peel Extract Hesperetin is one of our most competitive products with stocks available all year round. By providing superior quality, we establish long-term relationships with our clients.

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