Tangerine Peel Extract Tangeretin

What is Tangerine Peel Extract Tangeretin

The tangerine is a type of citrus fruit that is orange in color. Tangerine peel extract tangeretin, also known as 4 ‘, 5,6,7,8-Pentamethoxyflavone, is an O-methylated flavonoid derived from demethylated tangerine peel, found in the peel of citrus plants such as C. tangerina. The characteristics of tangeretin are colorless crystals or crystalline powders, with a foul and fragrant aroma. It is volatile, difficult to dissolve in water, and easily soluble in organic solvents such as ethanol and ether. Tangeretin can be hydrolyzed and hydrogenated to obtain naringin dihydrochalcone. Tangeretin is not only widely used in the fields of medicine and health products, but also has great potential for development in organic chemistry and life sciences.

How Tangerine Peel Extract Tangeretin Works

The mechanism of action of tangerine in anti-cancer is mainly to inhibit the proliferation, metastasis, and invasion ability of cancer cells in vivo.
The potential key mechanism of anti dementia effect of tangerine may include its inhibitory activity on β – secretase.
The antioxidant response of tangerine to the body is mainly achieved by clearing free radicals.
Tangerine can inhibit inflammatory response by suppressing the activation of inflammatory cells and the release of inflammatory mediators.

Health Benefits of Tangerine Peel Extract Tangeretin

Tangeretin has been associated with an array of potential health benefits, such as Antitumor, Treating Alzheimer’s Disease, Antioxidant, Antiinflammatory and so on, here we will browes some of its important Health Benefits as below:
Antitumor Activity
Many studies have shown that tangeretin has a certain inhibitory effect on a variety of tumors. For example, tangeretin can inhibit the migration and invasion of prostate cancer LNCaP, PC-3 cells, and can also inhibit metastatic breast cancer. Its targets include TP53, PTGS2, MMP9, and PI3K/Akt signaling pathways. Moreover, studies have found that tangeretin can inhibit the invasive ability of metastatic lung cancer cell lines, both in vivo and in vitro.
Treating Alzheimer’s Disease
The current treatment direction for neurodegenerative disease Alzheimer’s disease (AD) is through palliative drug therapy. In recent years, β – secretase 1 (BACE1) has been identified as a major drug target for reducing A β production and alleviating pathological changes in AD. Tangeretin can inhibit the activity of BACE1 by binding to it, thereby preventing the development of Alzheimer’s disease lesions.
Antioxidant
Like other flavonoids, tangeretin also has strong antioxidant properties. Its antioxidant effect not only clears free radicals in the body, but also stabilizes the cell membrane structure. Tangeretin can reduce the attack of free radicals on cellular DNA, proteins, and lipids in the body, and reduce the damage of oxidative stress to the body.
Antiinflammatory
Tangeretin also has significant anti-inflammatory effects. Inflammatory response is a defense response of the body against injury and infection, but excessive inflammatory response can lead to inflammatory diseases, so anti-inflammatory measures are crucial for the normal functioning of the body. In addition, the anti-inflammatory effect of tangeretin can also regulate the function of the immune system to alleviate inflammatory reactions.

Tangerine Peel Extract Tangeretin Side Effects

Tangeretin is a natural compound that generally has no side effects on the human body.

Where to Buy High Quality Tangerine Peel Extract Tangeretin

Henan Steeda Industrial Co.,Ltd is a Reputed Manufacturer and Supplier Supplying High Quality Pharmaceutical, Nutraceutical and Cosmeceutical Ingredients. Tangerine Peel Extract Tangeretin is one of our most competitive products with stocks available all year round. By providing superior quality, we establish long-term relationships with our clients.

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