Urolithin A
Product Name | Urolithin A |
CAS Number | 110-15-6 |
Molecular Formula | C4H6O4 |
Country of Origin | China |
Main Benefits | Used for Pharmaceutical and Nutraceutical |
OEM MOQ: 500 Units
Place of Origin: China
Bulk Package: 25kg/drum
Port: Shanghai, China
Payment terms: T/T, Letter of Credit, Western Union
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Urolithin A Reviews
Urolithin is divided into Urolithin A and Urolithin B. Urolithin A(UA)is a natural metabolite produced by the transformation of natural polyphenolic compound ellagitannins by the gut microbiota, belonging to the category of benzocoumarin or dibenzo- α- Organic compounds of pyranone. It cannot be directly supplemented from food. We can only obtain the raw materials for producing urolithin A, such as ellagitannins or ellagic acid, from food. Moreover, the amount of urolithin A synthesized in the body is not determined by consuming more food containing urolithin A precursors, but rather by the composition of the gut microbiota. In addition, its precursors, ellagitannins or ellagic acid, are mainly present in pomegranates, raspberries, blueberries, blackberries, walnuts, pistachios, and mountain walnuts, as well as in some teas, aged wines, and spirits. Research has shown that urolithin A has anti-inflammatory, anti-aging, antioxidant, and induced mitochondrial autophagy effects. It can cross the blood-brain barrier, inhibit PI3K/Akt/mTOR signaling, and has positive effects on skeletal muscle function, cardiovascular disease, etc. It has broad application prospects in dietary supplements, cosmetics, medicine, health products, and other fields.
Health Benefits of Urolithin A
There are so many Health Benefits of Urolithin A, here we will browes some of its important Health Benefits as below:
Urolithin A can activate mitophagy.
Mitophagy refers to the process in which mitochondria in cells undergo depolarization damage under reactive oxygen species (ROS) stress, nutrient deficiency, and cellular aging. In order to maintain the stability of the mitochondrial network and intracellular environment, cells selectively encapsulate and degrade damaged or dysfunctional mitochondria through autophagy mechanisms. With the increase of age and the occurrence of some age-related diseases, mitophagy will decrease or even stop, and gradually organ function will also decline, such as muscle decline in elderly people. However, urolithin A (UA) can activate mitochondrial autophagy through various pathways, such as activating enzymes that promote mitophagy, regulating the mitochondrial autophagy pathway, and promoting autophagosome formation. Some studies have found that the use of urolithin A in animals can prolong the lifespan of experimental animals or enhance muscle function.
Urolithin A can reverse immune system aging.
Hematopoietic stem cells refer to an important group of stem cells in the bone marrow that have self-renewal ability and can differentiate into various functional mature cells. They play a crucial role in maintaining the health of the blood and immune system. However, as age increases, the number and function of hematopoietic stem cells gradually decline, leading to immune system aging and the occurrence of related diseases. Studies have found that aging impairs the function of hematopoietic stem cells and is related to mitochondrial dysfunction. As long as the function of hematopoietic stem cell mitochondria can be improved, the vitality of hematopoietic stem cells can be restored. As a mitochondrial regulator, urolithin A can effectively restore the function of mitochondria in hematopoietic stem cells. Moreover, studies have found that when urolithin A is added as a dietary supplement, it not only activates the vitality of the lymphatic regions of the mouse immune system, but also enhances the overall performance of hematopoietic stem cells, demonstrating the potential of urolithin A to combat age-related immune system decline.
Urolithin A has anti-inflammatory effects.
Chronic inflammation of the body can weaken the immune system, leading to the development of many diseases. Urolithin A has anti-inflammatory and anti-aging biological activities. All clinical trials of urolithin A showed a common effect of reduced inflammatory response. The first discovery of this effect was in the colitis experiment in rats, where the mRNA and protein levels of the inflammatory marker cyclooxygenase-2 were reduced. More studies have found that other inflammatory markers, such as pro-inflammatory factors and tumor necrosis factor, are also reduced to varying degrees. Moreover, scientists from the University of Louisville have demonstrated that urolithin A can reduce and prevent inflammatory bowel disease (IBD). This is because urolithin A is abundant in the intestine, making it the most effective for inflammatory bowel diseases, including acute enteritis, ulcerative colitis, and even colon cancer. In addition, urolithin A can not only resist intestinal inflammation, as it lowers the overall serum levels of inflammatory factors. Therefore, theoretically, urolithin A can play a role in diseases caused by inflammation.
Urolithin A helps with weight loss.
Urolithin A can not only reverse muscle decline caused by aging, but the latest research has also found that it has an impact on cellular lipid metabolism and fat generation. Urolithin A can reduce the accumulation of triglycerides and fatty acid oxidation, as well as the expression of genes related to fat production. A recent mouse experiment has shown that urolithin A can induce brown fat activation and white fat browning, while preventing fat accumulation caused by diet. Brown fat is responsible for breaking down the white adipose tissue in the human body that causes obesity, converting it into carbon dioxide, water, and heat. It can accelerate the body’s metabolism and promote white fat consumption, so urolithin A can promote weight loss by generating brown fat in the body.
Urolithin A Side Effects
There is currently insufficient evidence to demonstrate the significant side effects of using Urolithin A related products on humans.
Where to Buy High Quality Urolithin A
Henan Steeda Industrial Co.,Ltd is a Reputed Manufacturer and Supplier Supplying High Quality Pharmaceutical, Nutraceutical and Cosmeceutical Ingredients. Urolithin A is one of our most competitive ingredients with stocks available all year round. By providing high quality, we establish long-term relationships with our customers.
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Product Name | Urolithin A |
CAS Number | 110-15-6 |
Molecular Formula | C4H6O4 |
Country of Origin | China |
Appearance | Powder |
GMO Status | NON-GMO |
Allergen | Allergen Free |
Sterilization | Non-Irradiated |
Grade | Could Meet Pharma Grade, Food Grade, Cosmetic Grade and Feed Grade |
Shelf Life | 2 Years if Sealed and Store away from Direct Sun Light |